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Available Components
 
Transfusion Medicine Service Available Components

The following blood components are routinely stocked by the Blood Bank:

For additional details please refer to the Circular of Information for the use of Human Blood and Blood Components which is published jointly by the following organizations: the American Association of Blood Banks, America's Blood Centers, and the American Red Cross. Copies of this pamphlet may be obtained by calling Blood Bank (5-7207).

Red Blood Cells (Adenine-Saline Added):

    These units are either derived from donation of whole blood or apheresis. The hematocrit is usually between 55-65 %.

Plasma:

    Plasma is dosed by patient weight: 10 mL/kg for correction of coagulopathy.

Platelets:

    Platelets collected by apheresis are the standard form of platelet utilized at this center. They contain the equivalent of at least 6 units of platelet concentrates derived from whole blood donations. The platelets are suspended in approximately 300 mL (i.e., one "unit") of plasma. An adult patient would be expected to experience a platelet count increment of approximately 20-40,000/ÁL from a single transfusion. Patients refractory to platelet transfusions are investigated by the Transfusion Medicine Service further to ensure provision of compatible platelets. Note: Patients expected to require ongoing platelet transfusion support should have their HLA type determined prior to initiation of any chemotherapy.

Cryoprecipitate:

    This component, derived from plasma, is most commonly used for augmentation of fibrinogen levels. The dosage is based on current fibrinogen and patient size; the adult dosage often involves exposure to 20 or 30 donor's blood. Multiple 10-unit pools of cryoprecipitate are maintained frozen for rapid thawing and administration.

Albumin (Human):

    Available in the following concentrations: 5%, 250 mL; 25%, 50 mL; 5%, 50 mL for pediatric use.

Coagulation Factor Concentrates:

    The following coagulation factor concentrates are stocked in the Transfusion Service laboratory:

    Antithrombin Three (AT3)
    Antihemophiliac Factor (Factor 8)
    Antihemophiliac Factor (Factor 9)
    Factor VIIa


*Granulocytes

*Red Blood Cells, Deglycerolized

Rho(D) Immune Globulin

    - Both standard (300 microgram) and micro (50 microgram) doses available.
    - Rho(D) Immune Globulin formulated for IV use is also available
    - Evaluation of candidacy and responsibility for ordering this product remains that of the attending Health Care Practitioner.

*Consultation with Transfusion Medicine Physician is required.

Specialized Components

NOTE:

    Component restrictions are placed in the laboratory's computer system. However, to ensure that the required component is being prepared, it is recommended that the necessary special handling be specified in the transfusion order as well.

Leukocyte-reduction:

    Prior to storage, cellular components are filtered to remove white blood cells (<5 E+6). Leukocyte reduction should not be used to prevent graft vs. host disease (GVHD). Reduction of Leukocytes reduces risk of febrile reactions, HLA alloimmunization, and CMV infection. ALL PLATELETS AND RED BLOOD CELLS ARE PRE-STORAGE LEUKOCYTE REDUCED AT DHMC. A "regular" 170 micron filter (blood administration set) should still be used at transfusion for both leukoreduced red cells and platelets.

CMV risk reduced:

    Leukocyte reduction is the method used for reducing the risk of CMV infection transmission in susceptible patients.

Irradiation:

    Gamma irradiation of cellular components is used to prevent donor lymphocyte proliferation following transfusion in certain immunosuppressed patients and the development of post-transfusion graft versus host disease. ALL CELLULAR COMPONENTS ARE IRRADIATED AT DHMC.

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